Home Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo
Shacter,‡ Peter L. Choyke,§ Chaya Pooput,¶ Kenneth L. Kirk,¶ Garry R. Buettner,‖ and Mark Levine*,**
*Molecular and Clinical Nutrition Section and
¶Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
†Radiation Biology Branch and the
§Molecular Imaging Program, National Cancer Institute, Bethesda, MD 20892;
‡Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892; and
‖Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242
**To whom correspondence should be addressed. E-mail: vog.hin.liam@Lkram
Communicated by E. R. Stadtman, National Institutes of Health, Bethesda, MD, March 27, 2007.
Previous articleAlarmin(g) news about danger: Workshop on Innate Danger Signals and HMGB1
Next articleOral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats.