Home    Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

Shacter,‡ Peter L. Choyke,§ Chaya Pooput,¶ Kenneth L. Kirk,¶ Garry R. Buettner,‖ and  Mark Levine*,**

*Molecular and Clinical Nutrition Section and
¶Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
†Radiation Biology Branch and the
§Molecular Imaging Program, National Cancer Institute, Bethesda, MD 20892;
‡Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892; and
‖Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242
**To whom correspondence should be addressed. E-mail: vog.hin.liam@Lkram
Communicated by E. R. Stadtman, National Institutes of Health, Bethesda, MD, March 27, 2007.